Students from all the schools in the Huron-Perth Catholic District School Board system will be taking part in the "Stuff That Bus" event Wednesday.
The tenth annual system-wide project allows students, staff and community members to support those in need.
The food drive will collect donated supplies and food for chapters of the St. Vincent de Paul Society in Stratford and Goderich.
Buses will travel across the two counties to collect and deliver the food donations from the Catholic schools.
Buses have been donated by First Student, Stratford and Goderich; Newry Coach Lines, Atwood; and Montgomery Bus Lines, Wingham.